Computer simulations of enzyme catalysis: Finding out what has been optimized by evolution
نویسندگان
چکیده
منابع مشابه
Computer simulations of enzyme catalysis: finding out what has been optimized by evolution.
The origin of the catalytic power of enzymes is discussed, paying attention to evolutionary constraints. It is pointed out that enzyme catalysis reflects energy contributions that cannot be determined uniquely by current experimental approaches without augmenting the analysis by computer simulation studies. The use of energy considerations and computer simulations allows one to exclude many of ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.11.5950